Sentence examples for major repair pathways from inspiring English sources

Double-strand break repair is executed by two major repair pathways: non-homologous end joining (NHEJ) and homologous recombination (HR).

UV damage to the chromosomal DNA in E. coli is mended by two major repair pathways: nucleotide excision repair and recombinational repair [28], [29].

Repair of mammalian chromosomal double-strand breaks (DSBs) entails use of one of two major repair pathways: non-homologous end-joining (NHEJ) and homologous recombination (HR) (reviewed in [1], [2], [3], [4]).

Although phenotypic differences and sequence variations can be observed from one strain to another, the use of major repair pathways such as HR and NHEJ remains unchanged.

The alternative RFCs channel cellular responses to DNA-borne stress into two major repair pathways: first, employing PCNA to enable replication resumption, and second, employing the cohesion complex to preserve the integrity of chromosomes.

It is known that three major repair pathways play essential roles in maintaining genetic fidelity under normal conditions, namely, somatic homologous recombination (SHR), mismatch repair (MMR) and cell-cycle checkpoint (checkpoint) [ 18- 21].

HR is widely considered as the major repair pathway in the mid-S and mid-G2 cell cycle phases, where DNA replication is maximum and therefore the sister template is accessible [18].

The joining step is usually done by the major repair pathway for double-strand DNA breaks, NHEJ.

Base excision repair (BER) is the major repair pathway for this lesion, with poly- ADP) ribose poly- ADPe 1 (PAriboseenzyme being one of its essential repolymerasedients.

However, HR is the minor repair pathway and is less preferred in the cell than NHEJ that is the major repair pathway.

A major repair pathway for damaged bases is base excision repair (BER), which involves a coordinated multistep mechanism involving a number of toxic and mutagenic intermediates.