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One of the major remaining issues is now to reduce the turnaround time from months to weeks, so referring clinicians can rely on exome sequencing as a rapid and robust diagnostic approach.
The manuscript has been improved but there are major remaining issues that need to be addressed before acceptance, as outlined below in the summary statement and review prepared by the Reviewing Editor.
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A major remaining issue was whether improvements in storm monitoring had distorted perceived trends in tropical-cyclone intensity, and researchers continued to analyze historical storm data to resolve the question.
One major remaining issue is to reduce sodium content while still providing the salty fix, to maintain food appreciation, acceptance and choice.
Kathie White, a spokeswoman for the union, said that although agreement had been reached in some areas, "the major issues remaining are big".
The manuscript has been improved but there are two remaining major issues that will need to be addressed before acceptance, as outlined below.
After the European Court decision, the major issue remaining is compensation: how much, for whom, in what form, over what period of time.
It remains unclear what exactly changed his mind, and two major issues remain to be worked out: the number of troops and how the commander will be selected.
A number of major issues remain on the table — for example, what will become of money from the cap-and-trade system, and will Internet poker be legalized?
Romania has been recently made progress, but some major issues remain unsolved.
But major issues remain, none of which will be easy to solve in the fractious tennis world.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com