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Transcription initiation is a major regulatory step in eukaryotic gene expression.
In particular, LOC_Os02g47470 encodes the ABA 8'-hydroxylase (OsABA8ox1), which catalyses the major regulatory step of the predominant pathway for ABA inactivation via the conversion of ABA to phaseic acid (Kushiro et al. 2004).
Because ROS is supposed to act upstream of JNK, inhibition of ROS accumulation by NF-κB is assumed to be one major regulatory step [44].
In its first major regulatory step to cut shipping emissions, CARB has targeted auxiliary engines on ships.
The recruitment of Gab1 to phosphatidylinositol-3,4,5-tris-phosphate within the plasma membrane by its pleckstrin homology domain is regarded as a major regulatory step for the activation of Gab1.
Our data are consistent with a model in which GSK3 phosphorylation of R2 and B could be one major regulatory step in APC2's dynamic cycle in the destruction complex, triggering release of the Arm rpts from the Axin complex, and thus allowing APC2 to promote βcat release for destruction.
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Major regulatory steps in these events are silencing of viral genes, continuous suppression of gene activities and finally stimulation of such activities followed by DNA synthesis.
These pathways play important roles in growth and development including secondary metabolism, and hence identification of major regulatory steps would be key to modulate plant performance and secondary metabolism, if need be.
Targeted therapy is an innovative research field in oncology, where the defects of major regulatory steps fine-tuning critical cell functions such as survival, proliferation and apoptosis serve as molecular targets.
In addition, ER stress caused increased polysome association of the mRNA encoding the major regulatory component for the rate-limiting step in GPI anchor biosynthesis, Dpm2, as well as the subsequent enzyme in the pathway, AfPIG-L.
The Federal Reserve moved Monday to overhaul the financial apparatus behind derivatives trading, a regulatory step intended to assure that the failure of a major bank or investment firm would not create the systemic threat seen in March after the collapse of Bear Stearns.
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