LldR, an FadR-type regulator, regulates lactate utilization in Pseudomonas aeruginosa.
PerR appears to be the major regulator of oxidative stress responses, regulating 74% of genes belonging to the cumene hydroperoxide stimulon, 73% of the genes in the menadione stimulon, and 85% of the genes in the hydrogen peroxide stimulon (with or without iron).
Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis.
SREBP1, which is negatively regulated by AMPK, is a major regulator of fatty acid synthesis [ 32].
SREBF2 (SREBP2) is a major regulator of cholesterol biosynthesis and it is primarily regulated post-transcription by membrane traffic and proteolysis [34].
In these cell lines, miR-328 may not be the major regulator of CD44 since CD44 can also be regulated by many other miRNAs.
More recent studies have shown that PML regulates the tumour suppressor p53, a major regulator of apoptosis.
First, of the genes belonging to the cumene hydroperoxide, menadione, and hydrogen peroxide stimulons, up to 75% are PerR regulated, indicating that PerR is the major regulator of the oxidative stress response.
In addition, hormone-sensitive lipase, a major regulator of adipose tissue lipolysis was demonstrated to be regulated by GCs [ 42].
Expression of miR-10b, a miRNA that promotes breast cancer cell metastasis by inhibiting HoxD10, is regulated by the transcription factor Twist, a major regulator of the epithelial-to-mesenchymal transition (Ma et al., 2007).
