Sentence examples for major regulated pathways from inspiring English sources

To identify major regulated pathways and processes, we evaluated the 500 most significant microbiota-regulated genes in each tissue for enrichment of functional gene categories.

To identify the major regulated pathways and processes under AB pressure, we evaluated the microbiota-regulated genes (mRNAs) (see table 1 in online supplement).

Genes involved in two major PPARα-regulated pathways were examined: mitochondrial fatty acid oxidation and peroxisomal fatty acid oxidation (Figure 4).

In the case of MB, important advances have also been made in the study of the major gene-regulated pathways that are altered in this tumor.

Three major IFN-regulated pathways involving RNA-dependent protein kinase (PKR)/the eukaryotic initiation factor (eIF -2α systeIF -2αA systemtase/RNase L system and Janus Kinase (JAK)/signal transducer and activator of transcription (STAT) system have been identified [ 9].

Our observation, that cell cycle genes are up-regulated in cells with metastatic potential compared to non-metastatic cells, is in agreement with some previously studies demonstrating cell cycle as the major up-regulated pathway in metastasizing breast cancer [ 5, 10].

This process is a major regulated mechanism for degrading long-lived proteins and the only known pathway for degrading organelles.

Among the up-regulated pathways were tricarboxylic acid cycle (TCA), oxidative pentose phosphate pathway, fermentation, gluconeogenesis, mitochondrial electron transport and minor and major carbohydrate (CHO) metabolism (Fig. 1, Additional file 6: Table S3).

UROA group showed various down-regulated pathways, including that of the inflammatory response.

Pathway annotation showed that there were 54 up-regulated pathways and 40 down-regulated pathways.

We examined the expression of genes regulating the metabolism of very low density lipoprotein (VLDL), a major pathway regulating hepatic triglyceride export; Apoa4 was highly up-regulated in ob/ob mice but its expression was not affected by TUDCA treatment.