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This class often consists of four to six highly conserved RNA-binding proteins, which suggests that major redundancy is present in this class.
It has been proposed that there is no major redundancy between these enzymes, at least in mammals, since knock-out mice for each PRMT display clearly different phenotypes [ 2].
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The dangers for the real economy if these are not addressed are that small and medium enterprises (SMEs), in particular, which employ some 13m people, would be forced to make major redundancies in order to survive.
Jardine said there was renewed optimism around the club after the playing staff agreed to wage cuts of up to 75% that allowed the club to avoid major redundancies.
However, because of the non-vital role and the likelihood of major functional redundancy in Plasmodium redox defence and ribonucleotide reduction, Plrx can largely be excluded as a valid target for antimalarial intervention strategies.
Worms lacking all three JmjD3 genes are viable and fertile and there is no evidence for a major functional redundancy between UTX-1 and the three JmjD3 proteins (Vandamme et al., 2012).
Notwithstanding major functional redundancies between Mfn1 and Mfn2 as promoters of mitochondrial fusion in MEFs, there are intriguing differences when the two mitofusins are individually deleted in mouse tissues using Cre-lox strategies.
The defeat of the welfare reform bill, due to a Sinn Féin/SDLP veto, has endangered other elements of the accord, such as the devolution of corporation tax powers, a major civil service redundancy scheme and new structures to address the legacy of the Troubles.
Intron retention was observed as a major cause of redundancy in the transcript collection and loss of proteins in the translations.
In a major reshuffle the redundancies announced in September also included the managing director roles at Heart and Galaxy, and the programme and marketing directors at Heart.
Last month, the Doha Film Institute – the cultural organisation behind the film and festival – laid off a third of its workforce, the second major round of redundancies in just over a year.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com