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The presence of only one SIRT1 allele was sufficient to cause a major reduction in the expression of many but not all of the CR-affected genes that depend on SIRT1.
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Achieving this goal will require a major reduction in the use of fossil fuels.
Therefore, no further major reduction in the cost of installed silicon solar panels is expected.
Perhaps most importantly, this analysis identified a number of cases that had major reductions in expression of the estrogen metagene with minimal impact on the proliferation metagene (for example, 145, 262, 263, blue arrows).
Similarly, the transcript level analysis showed a reduction in the expression of major members of the apoptotic machinery.
Based on differential gene expression data, there are major reductions in the levels of transcripts encoding FDFT-1 (farnesyl diphosphate farnesyl transferase-1), ABCA1 (ATP-binding cassette, subfamily A [ABC1] member 1), and the retinoic acid receptors, RRX and RAR.
Besides, curcumin plays a major role in the suppression of transcriptional activity of AP62 and HIF-1 and causes a reduction in the expression of VEGF [ 66].
We detected a significant reduction in the expression of the sterol regulatory element-binding protein 1c transcript in LKO, a major transcriptional regulator of lipogenesis.
These also suggest major reductions in the volume of summer sea ice, around 70% over the past 30 years.
Regarding combined exercise, 50% of studies reported a reduction in the expression of the receptors.
Conversely inhibition of P311 gene expression resulted in a reduction in the expression of TGF-β1.
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