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Major randomized controlled trials to determine the most effective antibiotic prophylaxis are difficult to construct and interpret.
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Two major multi-center randomized controlled trials (MC-RCTs) examining this question have now been performed: the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network (ATN) study [ 4] and the Randomized Evaluation of Normal versus Augmented Level (RENAL) Replacement Therapy Study [ 8].
The major objective of this randomized, controlled, multicenter study was to determine whether endurance exercise can improve muscle function in patients with PM/DM in a chronically stable disease phase.
'Improvement in efficacy/effectiveness' was also a major contributor but limited data (one randomized controlled trial of 6 months duration) [ 28] was criticized as not being sufficient for informed decision-making.
Randomised controlled trial OR randomized controlled trial.
We conducted a prospective, randomized, controlled study of high-risk patients undergoing major surgery.
This randomized, controlled trial conducted at community centers in Memphis, Tennessee requires major measurements at baseline and at 12 and 24 months post-randomization.
They also found that four prospective, randomized controlled studies failed to show a significant difference in major hemorrhage or thromboembolism.
Should we carry out a prospective, randomized, controlled trial of HVHF in sepsis with survival as the major endpoint?
Evidence-based reviews and meta-analyses of randomized, controlled trials conclude that routine antibiotic treatment does not provide major clinical benefits in adults with acute bronchitis [ 1- 7].
Such research needs to be conducted in a powered, randomized, controlled fashion to assess the effects on outcome of a peripheral perfusion targeted resuscitation following major abdominal surgery.
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