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Our finding of no association between HbA1c and cancer risk is consistent with the results of a recent meta-analysis of major randomised controlled trials.
Our aim was to synthesise data from major randomised controlled trials to estimate the comparative mortality effects of these devices and how these vary according to patients' characteristics.
Several major randomised controlled trials (RCTs) have shown reduction of complications with more intensive pharmacotherapy for hypertension, dyslipidaemia and hyperglycaemia in type 2 diabetes (T2D [ 3].
11 Which of these strategies is most effective is not known currently, and a major randomised controlled trial comparing active monitoring with radiotherapy and with radical surgery is not expected to report its findings before 2012.
Although depression is consistently associated in observational studies with poor outcome in people with both established CVD and with risk factors for CVD [ 7], all major randomised controlled trials (RCTs) have evaluated the effect of treating depression only in those with an established event such as myocardial infarction.
At present, two major randomised, controlled cardiovascular end point studies are ongoing, the LEADER 26 study and the EXSCEL study, 27 each including approximately 9000 patients.
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There are two major randomised control trials (RCTs) and a meta-analysis addressing whether controlling glucose in gestational diabetes is of value [ 6– 8].
Digoxin is used in patients with HF and has been shown in one major randomised control trial, the Digitalis Investigation Group study, to reduce the rate of hospitalisations in that population.
A seven-centre, parallel group, active controlled randomised controlled trial.
Dengue, American trypanosomiasis, the five major foodborne trematode infections, human African trypanosomiasis, dracunculiasis, mucocutaneous leishmaniasis, and Buruli ulcer each had 10 or fewer randomised controlled trials.
This is usually done using randomised controlled trials.
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