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5 The results of major randomised clinical trials on the benefits of such treatment are, however, controversial.
Endoscopic therapy is recommended as an alternative to oesophagectomy for patients with dysplasia The value of protocol based endoscopic surveillance to detect early cancer is yet to be established and is the subject of a major randomised clinical trial.
The authors of each chapter are to be congratulated for providing excellent up-to-date reviews backed by detailed and comprehensive lists of key references which include all the major randomised clinical trials and meta-analyses for the particular malignancy.
Recently, several major randomised clinical trials have yielded negative results regarding the effects of correcting anemia and reducing LDL-C on cardiovascular outcomes in patients with ESRD as well as that of raising HDL-C on reducing progression of atherosclerosis.
Even if this study had no control arm with the standard carboplatin paclitaxel chemotherapy, making it impossible to compare the OS obtained with our experimental regimens, we did try to compare the results with some of the major randomised clinical trials published in the last 20 years (Table 6).
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Yet the drug remains off-licence, and in the UK there's still no sign of any major randomised controlled clinical trials.
35 The major strengths of this randomised clinical trial are that it includes consecutive patients with a reasonable number of inclusion and exclusion criteria securing external validity for the results.
One in five randomised clinical trials published in six general major medical journals during 2005 and 2006 used a surrogate as a primary outcome.
Some recommendations in the guidelines are general for randomised clinical trials (RCTs), such as randomisation, double-blinding and placebo-control.
We assessed all published randomised clinical trials (n=626) during two years in six major general medical journals.
10 Prior to this trial we carried out a systematic review of randomised clinical trials examining the effects of psychodynamic therapy for major depressive disorder.
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