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Interestingly MHC molecules (known to transfer during trogocytosis [13]) but also tetraspanins are among the quantitatively major proteins found in these structures [25], [43], [54].
For example, among the major proteins found in the FBS-NB and γ-FBS-NB we identified consistently BSA and, to a lesser degree, BSF (Table 7), both deemed to be among the main calcium- and apatite-binding proteins found in the serum [91] [94], [99] [105].
Not surprisingly, albumin is one of the major proteins found in both human and bovine serum, where it is known to be present at concentrations as high as 35 45 mg/ml in human serum [52] and 23 mg/ml in FBS [53].
To the Editor: Class 2 and class 3 porin (PorB) proteins are the major proteins found in the outer membrane of Neisseria meningitidis (1 ); they function as porins, allowing the passage of small molecules through the outer membrane.
Because we know that one of the major proteins found in Lewy bodies, α-synuclein, is also a gene for PD when mutated (Polymeropoulos et al., 1997; Kruger et al., 1998; Zarranz et al., 2004) or if expression is increased without any sequence variants (Singleton et al., 2003; Chartier-Harlin et al., 2004), α-synuclein fulfils the requirements for a toxic agent in PD (Cookson, 2005).
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One study for example, showed that consumption of whey protein (a major protein found in milk) increased serotonin (a feel-good hormone first isolated at the Cleveland Clinic that is associated with mood elevation).
Calprotectin is a major protein found in the cytosol of inflammatory cells.
The envelope protein (E) is the most conserved of flavivirus structural proteins and is the major protein found on the virion surface [ 19].
As well, lipocalin-1, the major protein found in human tear fluid, has similarly been shown to be expressed in the prostate [ 27].
Thus, we hypothesized that silencing plakoglobin might affect cellular adhesion to fibronectin, a major protein found in fibroblastic foci in IPF [ 20, 39].
Apo A-I is the major protein found in HDL cholesterol and is a cofactor for lecithin cholesterol acyltransferase (LCAT), the enzyme required for reverse cholesterol transport metabolism [ 126, 127].
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