For major prognostic marker studies, the two kinds of data cannot be extracted directly.
LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer.
The invasion of bladder cancer into the muscle layer of the bladder serves as major prognostic marker for the development of the treatment plan [ 3].
Estrogens control multiple functions in hormone-responsive breast cancer cells [ 2], and ERα, in particular, plays a major role in the etiology of the disease, serving as a major prognostic marker and therapeutic target in breast cancer management [ 2].
In addition, these data highlight the importance of DNA methylation analyses in revealing components of breast cancers, like the immune component described here, that were not that apparent on the basis of classical gene expression analyses (the latter having revealed principally the cell proliferation component as the major prognostic marker for breast cancer (Sotiriou & Pusztai, 2009)).
Systematic reviews and meta-analysis are the standard methods to assess the association between prognostic markers and major events/conditions.
Complement and anti-dsDNA levels, however, are objective measures and routine laboratory tests that are widely available in clinical practice, and may be prognostic markers for major organ involvement.
Furthermore, the major implications of establishing interim prognostic markers during RT include: e) the validation of prognostic indices to predict clinical behaviour and assess toxicity risk and f) providing an insight into normal lung behaviour during RT, thereby presenting an opportunity to enhance patient management, including the delivery of individually adapted RT.
The lack of significant trends from 1984 to 2005 in these prognostic markers of HIV disease progression suggests no major change in HIV-1 virulence over the AIDS pandemic in MSM in the US.
A major goal of translational cancer research is to identify diagnostic markers, prognostic markers, and markers to predict response to treatment.
