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The major prognostic determinants for localised extremity STS are histological subtype, grade and size, with grade alone being the most powerful single prognostic predictor.
In addition, the prognostic significance of the extent of surgical resection has been identified in several series (MRC Working Party, 1990; Devaux et al, 1993), and histological grade and features, in particular necrosis, appear to be major prognostic determinants (Cohaden et al, 1985; Seung Kim et al, 1991; Salmon et al, 1994).
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The major prognostic determinant of colorectal cancer (CRC) is the pathologic stage of the tumor.
While the major prognostic determinant in lung cancer is stage at presentation, there is variability in survival for patients with same-stage disease.
The major prognostic determinant for patients with advanced colorectal cancer (CRC) with non-resectable metastases is the response to systemic therapy (Cunningham et al, 2010).
While the major prognostic determinant is stage at presentation, there is variability in survival for patients with same-stage disease, making it highly advantageous to identify further prognostic markers, which may predict patients likely to benefit from treatment.
Venet and colleagues confirmed that proliferation is a major prognostic determinant of outcome in unstratified breast cancer patients [ 11]. meta-PCNA was then used to adjust the expression data of breast cancer gene signatures, which resulted in a dramatic reduction in the association between most published and random signatures and outcome.
The intra-abdominal pressure (IAP) is an important clinical parameter with major prognostic impact [1, 2].
A major prognostic factor is the extent of tumour spread [13].
A major determinant of the lethal progression of HNSCC is the spreading of the malignant cells to regional lymph nodes which represents a major prognostic indicator (Forastiere et al, 2001).
The same applies to prognostic determinants for remission.
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CEO of Professional Science Editing for Scientists @ prosciediting.com