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We therefore opted for simpler models and restricted our focus to the study of the major processes implicated in transcriptional regulation (and described in the seminal Jacob and Monod paper [ 1]) rather than taking into account extensive details of the cell intracellular machinery.
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Although the cause of lower back pain is considered to be an interdependent multifactorial process, intervertebral disc (IVD) degeneration is one of the major pathological processes implicated [ 3– 5].
Glutamate excitotoxicity is a major pathogenic process implicated in many neurodegenerative conditions, including AD (Alzheimer's disease) and following traumatic brain injury.
Two books have been recently published with a major focus on strategies addressing cognitive processes implicated in weight loss and maintenance, 83, 116 and some studies found that adding cognitive procedures to lifestyle modification is associated with better weight loss maintenance.
Protein kinase A (PKA) is an important signal transduction target for drug development because it influences critical cellular processes implicated in neuropsychiatric illnesses such as major depressive disorder.
Non-resolving inflammation and prolonged neuroinflammation are unclear processes implicated in several conditions, including ageing.
Many cellular processes implicate large protein networks.
While hypertrophy of chondrocytes is a physiological process implicated in the longitudinal growth of long bones, hypertrophy-like alterations in chondrocytes play a major role in OA.
Another bacterial process implicated in virulence is quorum sensing [ 64].
Calpain-mediated proteolysis has been implicated as a major process in neuronal cell death including retinal neurological degeneration.
PLD is a major enzyme implicated in important cellular processes, such as cell proliferation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com