The response to and the toxicity of Ara-C treatment are characterized by significant interindividual differences, and the development of Ara-C resistance is still a major problem, raising the possibility that the pharmacogenetics of this agent may play a role in the difference of outcomes.
The bias introduced by the JIF arises directly from the major methodological problems raised against using citation analysis to evaluate journals.
The other major problems repeatedly raised by most of the respondents as barriers to the neonatal care were unavailability of roads and means of transportation and costs of transportation and services to take them to health facility for preventive and curative services.
Although, sleepiness was not considered as a major problem, it usually raised the concern of the parents about their child's post-operative safety.
Of equal concern are recent indications of increased incidence of coronary and metabolic complications associated with ADT which raises major problems of therapy toxicity that are beyond those related to the musculoskeletal system [ 14].
Staff did not raise any major problems with using these forms and felt that they succeeded in preventing residents being sent to hospital inappropriately (Q31).
This, however, raises two major problems: first, small nanoparticles (below 15 nm diameter) do not show a pronounced plasmon resonance because of a diminishing cross section, and second, a large surface-to-volume ratio heavily damps the plasmon resonance.
Lawmakers, experts and activists who spoke with The Huffington Post identified a lack of infrastructure to recruit African-American candidates as a major problem, along with troubles raising money and convincing the party establishment and voters to pick minority candidates.
Many of these cause major problems for their school and damage headteachers' efforts to raise standards".
The development of multiresistant bacteria (MRB) nosocomial infections has raised a major problem complicating the care of combat casualties [ 1].
