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The major problem is to characterize, even qualitatively, the distribution of electrical potential between the burner and sampling system for a flame of H2 + O2 + diluent, doped with Cs, at atmospheric pressure.
A major problem is to differentiate between subcanopy species that exhibit different traits.
As in diamond growth, the major problem is to suppress the growth of hexagonal phases (h-BN or graphite, respectively).
A major problem is to consider the GIF score as a continuous variable, which it is not.
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The teams did not know how many bots were at work so a major problem was to know when to stop searching.
One of the best ways to find out about any major problems is to ask the building's residents.
A major problem is how to best to analyze these data.
The major problem is where to discharge people to make room for the next emergency cases.
A major problem is attitudes to breast feeding, according to UN nutrition specialist Elham Monsef.
A major problem is how to understand whether pig proteins that are already available are informative enough to be useful in the annotation process (5, 6).
A major problem is going to be educating physicians who are, as yet, relatively uneducated about the availability of genetic tests to guide some of their prescribing decisions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com