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The major problem is that team teaching cannot be used in all subject areas.
A major problem is that confounding variables are not always known or measurable.
The major problem is that EIRENE is working with distances rather than time steps for calculating trajectories of the neutrals.
A major problem is that magnesium is low corrosion resistant and may undergo an environmentally induced degradation [ 4].
The major problem is that RA is a heterogeneous disease, with disease course and extent of connective tissue destruction varying considerably among patients.
Another major problem is that telemonitoring has the ability to produce a mass of data that require interpretation to be of use.
A major problem is that patients complain that doctors do not have feelings and often do not consider them as human beings (i.e., as equals).
A major problem is that the majority of the cells die during the first 3 weeks following transplantation.
A major problem is that there is little co-ordination of learning across placements and universities.
A major problem is that the machines get out of calibration.
A major problem is that the evidence base for yoga is not there.
More suggestions(15)
major inconvenience is that
major flaw is that
major challenge is that
major aspect is that
major constraint is that
major drawback is that
serious problem is that
major issue is that
principal problem is that
major worry is that
major factor is that
major one is that
major criticism is that
major disappointment is that
major learning is that
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com