Sentence examples for major problem however from inspiring English sources

There was one major problem, however, and it sufficed to bring down Cartesianism.

There is one major problem however: The biggest telecommunications players come from an entirely different mindset than the high-growth, go-go, data networking firms.

A major problem, however, was that many contenders never considered the actual conditions of the contest, and so not one proposal aroused the board's interest for over 15 years!

One major problem, however, has been that when an electric voltage is applied across the film, DNA tends to move through the nanopore too quickly to read off all the bases in sequence.

A major problem however exists in this regard.

There's a major problem, however, with a CO2-centric strategy.

It still faces major problems, however.

There are at least two major problems, however.

Northwest still faces several major problems, however.

Italy is not without major problems, however.

One of the major problems, however, is to identify which of these genes are linked to viral clearance in vivo.