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This explanation already proposed by Irimia et al. [ 12] is in agreement with the phylogenetic analyses, but is faced with one major problem, explaining why in several independent lineages there have been similar pressures to keep the duplicated genes in clusters.
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Stead did not really highlight a major problem, Ringdal says, explaining: "There were few underage British prostitutes in other countries and very little demand for them.
Outright tax evasion by the super rich and many of those on middle incomes is also a major problem, as Yogita Limaye explains.
They explained that the major problem with the Perrin equation is that it treats the protein as a smooth ellipsoid, when in fact the surface of the protein is quite rough.
Generally there are no major problems with communication, but explaining the type of pain is sometimes difficult.
The major problem of the CEC analyses was to explain the origin of the differences found in the core samples.
Black-white tension isn't the major problem of our moment, and racism doesn't explain the motivations of any of the major players in our politics.
In "The vindication of Sumner Redstone," Robert Lenzner and Peter Newcomb explain how Redstone confronted and dealt with his major problem.
(Umm…), "It looked like there's a major problem to be solved and no one had really solved," he explained.
One major problem of the faster-male theory is that it can only explain Haldane's rule under male heterogamety.
It's a major, major problem.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com