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3 However, the major predisposition factor for breast cancer is a positive family history of the disease.
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In a particular set of 29 genes related to major cancer predisposition syndromes, we also observed 141 concurrent CVs.
Previously published family and sibling studies have pointed at a major family predisposition to advanced primary hip OA [ 16– 16].
Furthermore, on the basis of our data the two major NB predisposition genes can be excluded to lead to the reduction of the OXPHOS enzyme activities in NBs.
It has long been established that the major genetic predisposition to this disease is contributed by variants of the class II HLA gene, HLA DRB1.
Previous studies including ours, however, have lead us to rule out RUNX3, Caspase-10, SMAD4, HPP1, and Desmoglein 2 as major GC predisposition genes in families with aggregation of gastric carcinoma (12– 12).
Their major problems are predisposition to tearing out and microbial diseases.
Furthermore, evidence suggests that nutrition during pregnancy contributes to intrauterine immune and metabolic programming in the offspring, which may have major influences on predisposition to cardiovascular, metabolic, and allergic diseases, including asthma, later in life.
The same region also binds PALB2 protein linking BRCA1 to another major breast cancer predisposition gene BRCA2.
Overall, these results suggest that chronic prostatic inflammation may be a major factor in predisposition to prostatic carcinogenesis.
These results suggest that common variations in ALG9 do not play a major role in predisposition to bipolar affective disorder.
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