"major practical issues" is a grammatically correct and usable phrase in written English
It can be used to describe a situation where there are many significant practical problems that need to be solved. For example, "The project has encountered several major practical issues that need to be addressed before we can proceed."
Breaking into the data centers is a major practical issue, but there is every reason to be enraged by the smiley face, too.
As we have mentioned before, in many real-world applications, the lack of labeled data poses a major practical issue for many network classification tasks.
The last major practical issue in the decision to use charcoal for decontamination of a poisoned patient revolves around time of ingestion.
This is a major practical issue, because the matrix inversion operation in RZF precoding is very computationally demanding in large systems [35]; the number of operation scale as (mathcal {O}(K^{2} M)) and the known inversion algorithms are complicated to implement in hardware (see Section 4 for details).
The major "practical" issue was not so much space as it was energy, and we calculated that the system would require the equivalent of the output of two dozen nuclear plants for heating, lighting and construction.
Aside from the analytical performance of the two barrier materials, foaming of the sample was a major practical issue.
A major practical issue in the analysis of individual case reports to uncover possible new drug risks is their sheer numerosity.
Nevertheless, as one of the first of its type, this book fairly comprehensively grapples with the major theoretical and practical issues facing researchers in culture and disasters.
This paper conducts a review of research in conceptual model quality and identifies the major theoretical and practical issues which need to be addressed.
Participants reported very limited access to specialist dementia physicians but none appeared to see this as a significant support gap, largely because most of their major concerns revolved around practical issues of day-to-day management, which were being well met by professional in-home care providers.
