Our study had at least 1 major potential limitation.
A major potential limitation inherent in surveillance studies that measure in vitro antimicrobial drug resistance is their clinical relevance.
A major concern and potential limitation of the RNA-guided nuclease system is the possibility of cleavage and deleterious editing at other sites in the genome (off-target sites) in addition to the on-target site (Fu et al. 2013).
Although the two study designs we employed have major strengths, they are not without potential limitations.
Potential limitations of the DNM should also be considered; a major theoretical concern is incomplete sampling of data.
It then describes major potential data sources for such endeavors, including information regarding access and insights regarding the strengths and limitations of each.
Despite these limitations, the main advantage of the current study is the high response rate that excludes one major potential source of bias in the results.
In spite of the potential limitations of the study design, our data are reassuring that acrylamide seems unlikely to be responsible for a major fraction of these cancers.
It also shows the potential limitations of referendums.
