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The six (major) points raised by reviewer #1 should be addressed by the authors.
We responded these issues at the #3 of the Major points raised by the editors and the reviewers.
Therefore, if you think you can address the three major points raised we would be happy to reconsider the manuscript.
We will comment (agreeing with him that such opinions cannot be judged) on two of the major points raised by Dr. Doolittle.
The major points raised that need to be addressed are: 1) The authors nicely cite and describe the importance of Notch signaling for tip-stalk cell formation and the possible role of Gpr124/Reck in this scenario.
Finally, we performed the in vivo tumor forming assays using the anti-miR-142-3p-expressing anti-miR-142-3p-expressing anti-miR-142-3p-expressing anti-miR-142-3p-expressing anti-miR-142-3p-expressing reviewers #3. 5) From thumansults presented in Figure 5, the authors conclude in the corresponding text that miR-142 upregulates miR-150 via the canonical Wnt signaling.
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Wilde's violation of class borders in consorting with grooms, valets and coachmen was a major point raised against him in court — and one he did not honestly answer.
A major point raised by Baethge et al. as well as Martino et al., which we would partly agree with, is that those with multiple episodes have a worse prognosis than those with a first episode who would be made up of a group with varying prognoses (though unknown at the time of sampling).
Given the major point raised above, this should be replaced with a more nuanced statement.
5) Again, given the major point raised above, the first paragraph of the paper goes from citations of historical work to citations of very general works on enzyme mechanism.
This finding echoes a major point raised by Carneiro and Mylonakis (2 ), namely, that without adjusting for spikes driven by disease publicity rather than the disease itself, Internet searches may lose much of their value in supplementing traditional surveillance measures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com