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When at 5 min after the onset of flow, c7E3 Fab (0.1 10 μg/ml) and rt-PA (1 μg/ml) were coinjected in flowing blood, it was found that modest fibrinolysis caused major platelet release from fibrin substrates and there was no difference in the lysis rate in the presence of rt-PA+c7E3 Fab compared to rt-PA alone.
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Cytoskeletal mechanics of proplatelet maturation and platelet release.
The specific resultants of platelet release (GMP140) were tested for evaluating the platelet activation.
Sirois, M., Simons, M., Edelman, E.R., Kuter, D.J. & Rosenberg, R.D. Platelet release of platelet-derived growth factor is required for intimal hyperplasia in rat vascular injury model.
Introduction: Platelets enhance leukocytic phagocytosis via the action of ATP and ADP in platelet release products (PRPr).
However, overexpression of Bcl-xL results in impaired platelet release.
PF-4 is released from α-granules in activated platelets during aggregation in a platelet release reaction.
Snake venom serine proteinases also act on platelet-rich plasma or washed platelet suspensions promoting platelet-aggregation and platelet release reactions [ 8, 36].
GPS, gravitational platelet separation; PCCS, platelet concentrate collection system; PRF, platelet rich fibrin; PRGF, platelet released growth factor; PRP, platelet-rich plasma.
Activated platelets release several vasoactive mediators including serotonin.
At the sites of vascular injury, activated and aggregating platelets release small vesiculated structures called platelet microparticles (PMPs).
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