Sentence examples for major physiological targets from inspiring English sources
Among the major physiological targets of the Hmt1 methyltransferase are heterogeneous nuclear ribonucleoproteins (hnRNPs) [43], [44], which bind mRNAs during processing and export from the nucleus [7], [8].
Myogenin and p21CKI have been identified as the major physiological targets of endogenous myostatin in murine cells [ 19].
Myogenin and p21CKI have been identified as the major physiological targets of endogenous MSTN in murine cells [ 14].
These rescue experiments demonstrate that p27 is a major physiological target of SCFSkp2, whereas accumulation of cyclin E alone is not responsible for the cellular abnormalities of Skp2−/− mice.
In summary, the name of the serpin would ultimately depend on experimental evidence for the identity of the cleavage site but only with a proteinase that was shown to be the major physiological target.
Hence, the biochemical and cell biological evidences from the current work, and the available genetic evidence are consistent with the conclusion that Nrg1 is the major physiological target of Aph1bc-γ-secretase in vivo in the context of synapse formation.
ERα upregulates or downregulates the transcription of hundreds of genes [ 41] and PR is a well-known ERα target gene with a major physiological role in cell proliferation.
We begin to address the physiological targets of the Leishmania ISPs by creating L. major mutants deficient in ISP2 and ISP3 and characterizing their phenotype during the early phases of macrophage infection.
After understanding the mechanism of interaction between aspirin and the vascular endothelium, Vane proposed assigning a major physiological function to the vascular endothelium which then became a pharmacological target for new drugs.
NADH dehydrogenase is regarded as the major physiological and pathological site of reactive oxygen species (ROS) generation in mitochondria, and as a target of assault by ROS [ 28].
The major physiological difference of interest between the samples analyzed was coat color, so we focused on potential target genes regulating pigmentation.
