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Factors that influence the susceptibility to, and progression of, these major phenotypic forms are currently unknown.
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Another major phenotypic class of developmental mutants – those that form aerial hyphae but do not sporulate efficiently – identified the whi genes, so-called because the mutants fail to accumulate spore pigment in their aerial mycelium, which remains white on prolonged incubation (Hopwood et al., 1970; Chater, 1972).
This phenotypic analysis focused on easily scored phenotypes in order to determine if there was major phenotypic diversity in the collection.
However, the majority of individuals did not experience motor auras, and furthermore, major phenotypic differences were observed between a set of monozygotic twins.
However, extinction of a majority of the nuclear OXPHOS genes caused early embryonic death or produced no major phenotypic abnormalities.
The LOD score is highly significant (P < 0.0001) indicating a major phenotypic effect of Bsdr1.
The gene-disruption mutants segregated from NG6441 and the WT were grown under controlled conditions to assess major phenotypic differences.
The twins shared many clinical similarities but also exhibited major phenotypic differences, despite having the same genetic background and living in the same environment until their teenage years.
Given these observations, the explanation for the absence of any major phenotypic abnormalities in Maestro-deficient mice is unclear.
This major phenotypic switch in pancreatic cancer cells may be driven by the epithelial-mesenchymal transition (EMT).
The transgenic line exhibited no major phenotypic alterations.
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