Sentence examples for major phenotypic changes from inspiring English sources

The major phenotypic changes in the transformation of meningioma from the classic to the anaplastic type are loss of meningioma architecture, decreased expression of epithelial membrane antigen, increased expression of vimentin, and metaplastic expression of alpha-internexin and neurofilament triplet proteins.

These findings thus confirm that lysogeny of B. anthracis is associated with major phenotypic changes and the acquisition of at least two new niches in the laboratory.

Reverse genetic studies are needed to determine if any of these substitutions cause major phenotypic changes.

Thus, hub genes can help identify new biomarkers of tumor progression, metastasis and other markers of major phenotypic changes.

The key finding of this Raman mapping study is that E6 oncoprotein expression induces major phenotypic changes in the cells which are also targeted by an HIV antiviral drug—Indinavir [ 43].

Since PrP knock-out mice [ 30] and cattle lacking the prion protein [ 31] show no major phenotypic changes, another gene, possibly SPRN, might take over the physiological function of the prion protein.

It has been documented in primary gastric cancers, that major phenotypic change in cancer-associated myofibroblasts is a global reduction in DNA methylation [ 17].

Treatment of SL2 cells with an inhibitor of pyridoxal phosphate synthesis resulted in both a similar pattern of expression as that found by SPS1 knockdown and the formation of megamitochondria, the major phenotypic change observed by SPS1 knockdown.

Recent progress in cloning causal genes involving major phenotypic change within natural variation, such as seed shattering, seed size and growth habit, has further elucidated the rice domestication process.

According to gradualistic models, there should be no correlation between cladogenesis and anagenesis (between speciation and changes in the phenotype of organisms) while punctuational models of any class assume that major irreversible phenotypic changes are always associated with speciation.

SNPs which, if strictly defined, occur in at least 1% of a normal population, are estimated to occur once every 100-300 bases in the human genome [ 3], giving rise to subtle phenotypic variation without causing major deleterious phenotypic changes; PDs occur at much lower frequencies and are causative of disease.