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Two major pathways leading to apoptosis have been described with CPT-treated cells: the death receptor pathway involving the activation of caspase-8, and the intrinsic mitochondrial pathway mediated by mitochondrial release of cytochrome c and caspase-9 activation.
These recent findings identify XAF1 as a candidate tumor suppressor at the junction of several major pathways leading to apoptosis.
There are two major pathways leading to induction of cellular senescence: the p38 mitogen activated protein kinase (MAPK /p16INK4a pathway and the p53/p21cip pathway.
On the other hand, Buja et al. (1993) suggested that the initial modifications of cellular metabolism and calcium homeostasis may activate major pathways leading to a loss of membrane integrity by a) membrane phospholipid degradation, b) production of amphipathic lipids, c) damage of the cyto-skeleton, and d) generation of toxic oxygen species and free radicals.
Of these, 18 pathways relevant to pods were presented in Additional File 3. As expected, five major pathways leading to the production of sugars and starch involving the enzymes UDP-glucose pyrophosphorylase (EC:2.7.7.9) and dTDP-glucose 4-6-dehydratase (EC:4.2.1.46) were identified.
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Mallucci's team have found a major pathway leading to brain cell death in mice, and used an oral compound to block it.
DBF can be catabolized by P. putida B6-2 via two pathways (Fig. 1b), with the major pathway leading to the accumulation of HOBB (Li et al. 2009).
Accumulation of silver ions (Ag+) released from AgNPs are supposed to be the major pathway leading to body burden following exposure to test media containing AgNPs.
Silver ions (Ag+) released from AgNPs are supposed to be the major pathway leading to body burden following exposure to test media containing AgNPs.
Accumulation of silver in the animals exposed to the different treatments was apparent, whereby silver ions (Ag+) released from AgNPs were supposed to be the major pathway leading to body burden.
Autophagy constitutes the major pathway leading to lysosomal degradation [23].
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