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The major pathways involved in this cross-talk are the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system [13 15].
The major pathways involved in skin, vascular, and bone regeneration, and in muscle force transduction are outlined, along with examples of how tissue engineers can exploit cell signaling.
Sphingomyelinase-dependent hydrolysis of sphingomyelin and de novo synthesis involving the coordinated action of serinepalmitoyl transferase and ceramide synthase are the two major pathways involved in ceramide synthesis.
In each case, the data indicate the major pathways involved and the many ways that mutations can modulate those pathways.
Non-homologous end-joining (NHEJ) is one of the major pathways involved in repairing double-strand breaks (DSB) in DNA.
The major pathways involved in dauer formation are the transforming growth factor β (TGF-β), insulin/insulin-like (IIS) and guanylyl cyclase pathways [6].
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Lipoxygenase-derived hydroperoxy fatty acids are metabolized through major pathways involving enzymes such as the hydroperoxide lyase [ 59].
Another major pathway involved in senescence is the p16/Rb pathway [38].
Autophagy is the major pathway involved in the degradation of long-lived proteins and organelles, cellular remodeling, and survival during nutrient starvation [25], [26].
Macroautophagy (in this paper referred to as 'autophagy') is a major pathway involved in the degradation of long-lived proteins, protein aggregates, and organelles, cellular remodeling, and survival during starvation [27], [28].
These results indicate that ERK is not the major pathway involved in cell death resistance.
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