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The human genetic studies implicate some major pathways in the pathogenesis of IBD, including epithelial defense against commensal microbiota, the IL-23/Th17 IL-23/Th17immune regulaxisn.
Additionally, they demonstrated that the SPOP mutation activates two major pathways in prostate cancer — androgen receptor signaling and phosphoinositide 3-kinase (PI3K) signaling — which are both important to cell survival and growth, and are processes that contribute to malignancy.
To expand the utility of quantitative proteomics for metabolic engineering, we validated and optimized targeted proteomics methods for over 400 proteins from more than 20 major pathways in E. coli metabolism.
There are five major pathways in the brain connecting other brain areas with the basal ganglia.
Thus the question arises; if gzmB's broadly induced apoptosis can only be mediated by one of the two major pathways in virus infected target cells.
CMA specifically degrades the oxidized proteins in cytoplasm and is one of the three major pathways in autophagy; however, it is considered an atypical function of lysosomes [19].
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Our results suggest that nitroreduction is the major pathway in the human bioactivation of 3-NBA.
Reduction of nitrate to ammonium was also not a major pathway in either network, contributing <4%.
The discovery suggests that scientists may be able to regulate a major pathway in the brain responsible for appetite and fat-building.
It serves as a major pathway in perineural spread of pathologies such as head and neck neoplasms, automatically upstaging tumours, and is a key structure to assess in cases of trigeminal neuralgia.
The kynurenine pathway is the major pathway in the metabolism of tryptophan.
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