Sentence examples for major pathways implicated from inspiring English sources

In this review, we explore some of the major pathways implicated in cervical cancer development, including RAF/MEK/ERK, phosphatidylinositol-3 kinase (PI3K/AKT), Wnt/b-catenin, apoptosis and coupled membrane receptor signaling.

We used this model to inactivate the NODAL and SHH pathways, both major pathways implicated in human HPE, during forebrain development.

The role of these pathways during forebrain development has been extensively studied, especially the SHH and NODAL pathways, the two major pathways implicated in the pathogenesis of HPE (Roessler and Muenke, 2010).

Indeed, the effect was also blocked by inhibitors of the MEK-Bcl-2 pathway, the major pathway implicated in BDNF-TrkB-dependent neuroprotection [ 56].

The current review is an attempt to cover and establish an understanding of some major signaling pathways implicated in prostate cancer development and castration-resistance, besides addressing therapeutic strategies that targets the key signaling mechanisms.

These observations suggest that maternal protein restriction can affect major metabolic pathways implicated in regulation of lifespan at a young age which may explain the impact of maternal diet on longevity.

Thus, we concluded that the effect of acupuncture stimulation at GV20 is interrelated with primary alternation of ChAT and AchE activities as changes of the cholinergic system, furthermore, there are several major signaling pathways implicated in learning and memory [ 55].

PI 3-kinase pathway is pivotal in the regulation of EPC proliferation, recruitment and mobilization and its impairment in insulin resistance states seems to be a major molecular pathway implicated in reduced EPC counts and increased arterial stiffness [ 15].

The exact pathways implicated in these processes need further investigation.

Alternate pathways implicated in tumor growth also exhibited upregulation such as VEGF signaling with 49 molecules.

To address these major questions, we evaluated the effect of P140 administration on the expression of HSC70 and MHCII molecules, and studied the possible influence of P140 on autophagosomal pathways implicated in the endogenous MHCII loading.