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The major pathway that handles 95% of MetHb under physiological conditions is the Embden-Meyerhoff pathway in which there is an enzymatic reduction of MetHB to Hb by the enzyme NADH (nicotinamide adenine dinucleotide) MetHb reductase [3].
The reduced state under oxygen limitation will probably restrict TCA cycle, which is the major pathway that generates NADH, to keep redox balance.
A major pathway that is upregulated in response to ionizing radiation is the p53 pathway.
Endoplasmic reticulum (ER) stress is another major pathway that regulates the expression of VEGF under adverse environmental conditions.
In addition to this, another major pathway that promotes apoptosis in cancer cells is the death receptor-mediated pathway (extrinsic pathway) [ 7].
Thus, while apoptosis is a major pathway that causes muscle weakness in OPMD, other cell death pathways may also contribute to the disease when apoptosis is inhibited.
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Our study pinpoints SENP7 as a novel determinant in epigenetic programming and major pathways that govern oocyte and embryo development programs in mammals.
Apoptosis is one of the major pathways that lead to the process of cell death [27].
These three pathways are of the major pathways that are responsible for the biosynthesis of bioactive compounds in ginger such as flavonoid and volatile oil.
The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms' development.
The major pathways that contribute to differentiating the sites follow the division between bacteria and archaea-specific pathways (Figure 4a).
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