Sentence examples for major pathophysiological defects from inspiring English sources

77 In T2D, insulin resistance and β-cell failure remain the major pathophysiological defects; however, mounting evidence suggests that islet inflammation also plays an important role in the loss of functional β-cell mass in T2D.

Analysis of the biochemical impacts of PTPN11 mutations first identified both loss-of-function and gain-of-function mutations, as well as more subtle defects, highlighting the major pathophysiological consequences of SHP2 dysregulation.

A defect in hydrogen ion secretion is the major pathophysiological mechanism leading to distal RTA.

Our understanding of the pathophysiology of diabetes has progressed over time with recent research identifying eight pathophysiological defects, termed the "ominous octet," involved in the development of diabetes.

Type 2 diabetes is a complex major endocrine disorder in which insulin resistance in the muscle and liver as well as β-cell failure represent the core pathophysiological defects.

It has been assumed that specific epilepsy syndromes are associated with specific underlying pathophysiological defects.

The major pathophysiological mechanisms leading to hyperchloraemic metabolic acidosis after fluid resuscitation with saline remain controversial.

Atherosclerosis is recognised as the major pathophysiological process which underlies most cardiovascular diseases including transient ischaemic attacks (TIA) and strokes.

Reduced level of blood flow and enhanced inflammation are the two major pathophysiological changes that occur in the ischemic tissue.

Hypoxia is a major pathophysiological trigger of angiogenesis.

Accordingly, a reduction of the bile acid pool size and the cholesterol supersaturation of gallbladder bile were identified as pivotal pathophysiological defects that promote cholesterol gallstone formation [23] [27].