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Given that two of the major pathological sequelae of TBI involve a generalized neuroexcitation insult and diffuse axonal injury, we have employed models of these pathologies, delivered either independently or in combination, to examine their effects on injury-induced synaptic reorganization of the dentate gyrus in the developing rat.
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Monocytes are a major element of the innate immunity defense to pathogen invasion, but their overly-robust response can lead to pathological sequelae resulting in tissue damage.
Intracerebral complement activation after severe traumatic brain injury (TBI) leads to a cascade of neuroinflammatory pathological sequelae that propagate host-mediated secondary brain injury and adverse outcomes.
ROS constitute a major pathological factor causing many serious diseases, including cancer and neurodegenerative disorders [32].
Only < 10% tumor cells were viable in all resected specimens, indicating major pathological response to alectinib.
The death of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD).
Pathological examination revealed that only < 10% tumor cells were viable in all resected specimens, indicating major pathological response to alectinib (Fig. 3).
We next investigated whether pathological sequelae associated with hyperphosphorylation of tau in AD were also present in brain sections from sod2 null mice.
Epidemiological studies have shown that 15% 30% of unborn babies who acquire congenital HCMV infection display a variable pattern of pathological sequelae within the first few years of life that may include hearing loss, vision impairment and mental retardation [2].
Silicotic nodules are known as the major pathological character of silicosis.
A major pathological hallmark of AD is the deposition of insoluble extracellular β-amyloid (Aβ) plaques.
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