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Seven of 10 patients with PDA had major pathological responses.
Of the 10 patients with PDA, 1 had a complete pathological response, 6 had major pathological responses (GRT-1), 1 had a partial response (GRT-2) and 2 did not response (GRT-3).
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Only < 10% tumor cells were viable in all resected specimens, indicating major pathological response to alectinib.
Pathological examination revealed that only < 10% tumor cells were viable in all resected specimens, indicating major pathological response to alectinib (Fig. 3).
We presented the first case of ALK-rearranged lung adenocarcinoma with major pathological response in resected specimens after treatment with alectinib.
Here, we present the first surgical case of ALK-rearranged lung adenocarcinoma with major pathological response in resected specimens after treatment with alectinib.
Bevacizumab in combination with oxaliplatin/fluoropyrimidines can provide the highest major pathological response rate [15], and the pathological response to induction chemotherapy has been shown to correlate with improved survival [16].
Here, we report the first case of ALK-rearranged lung adenocarcinoma with major pathological response in resected specimens after treatment with alectinib, which may provide a pathological rationale for its greater clinical efficacy for advanced patients and may warrant clinical trials of adjuvant treatment of alectinib for resectable ALK-rearranged NSCLC patients.
Major pathological response (MpR) in breast tissue was defined as no more than 2 cm of residual disease (pT0 plus pT1) [ 27].
Peri-prosthetic high bone turnover is thighajor pathological response to aseptic loosening, so local boneturnovert may be preferable for local hish bone thenover-related diseases.
Overall, the impact of pre-operative treatment on survival depends on achieving a major pathological response at oesophagectomy (Swisher et al, 2005; Brücher et al, 2006).
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