Sentence examples for major pathological pathways from inspiring English sources

The AD hallmark pathways are amyloid β cleavage, amyloid β degradation, APOE-cholesterol pathway and NFT accumulation, which are major pathological pathways of AD.

About a quarter of patients with CP do not have clinically recognized AP prior to diagnosis (below), but the fact that the majority of CP patients do have such a history suggest that this is a major pathological pathway as envisioned in the Sentinel Acute Pancreatitis Event model.

Whilst the etiology of DR is highly complex and not fully understood, hyperglycemia has been accepted as the major pathological factor contributing to the development of DR. Four distinct glucose metabolic pathways are activated by hyperglycemia: 1 Diacylglycerol (DAG)–protein kinase C (PKC) pathway.

Curcumin, the major component of turmeric Curcuma longa, has been described to own benefic effects in pathological pathways common of both inflammation and carcinogenesis.

In higher eukaryotes, major pathological cellular processes are associated with altered NPCs, and many viruses target components of the nucleocytoplasmic transport pathway to usurp it (Faustino et al. 2007; Chahine and Pierce 2009).

This overlap between PD and AD suggests that common pathological pathways exist for the two diseases.

ROS constitute a major pathological factor causing many serious diseases, including cancer and neurodegenerative disorders [32].

Only < 10% tumor cells were viable in all resected specimens, indicating major pathological response to alectinib.

The death of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD).

Pathological examination revealed that only < 10% tumor cells were viable in all resected specimens, indicating major pathological response to alectinib (Fig. 3).

A major pathological hallmark of AD is the deposition of insoluble extracellular β-amyloid (Aβ) plaques.