Sentence examples for major pathological hallmark from inspiring English sources

Abundant extraneuronal deposit of amyloid-beta (A β) is the major pathological hallmark and plays an early important pathologic role in the development of AD.

The major pathological hallmark of AD plays an early and important pathologic role in the development of AD.

The death of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD).

The aggregates of α-synuclein (αS) are a major pathological hallmark of Parkinson's disease (PD) making their structure-function relationship important for rational drug design.

A major pathological hallmark of AD is the deposition of insoluble extracellular β-amyloid (Aβ) plaques.

As the major pathological hallmark of OPMD consists of intranuclear inclusions formed by deposition of PABPN1 fibrils, we next analyzed the sub-cellular distribution of proteins identified as preferentially associated with expanded PABPN1.

The major pathological hallmarks of multiple sclerosis (MS) comprise inflammation, demyelination with associated gliosis and axonal damage, which most likely correlates with persisting disability.

Major pathological hallmarks of Parkinson's disease are the death of neurons in the substantia nigra, a region of the brain associated with movement, and the presence of intraneuronal aggregates of α-synuclein.

The two major pathological hallmarks of AD are the progressive loss of cholinergic neural transmission, formation of a beta-amyloid plaques (Aβ-plaques) that forms senile plaques (SPs) and neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein [4, 5].

The mechanism by which ApoE isoform affects risk of AD is uncertain, with roles proposed in all three of the major pathological hallmarks: Cell death [11], neurofibrillary tangles [12], [13] and senile plaques [3], [14].

Synaptic loss is one of the major pathological hallmarks of AD.