Sentence examples for major pathological feature from inspiring English sources

Ubiquitin-immunoreactive neuronal inclusions composed of TAR DNA binding protein of 43 kDa (TDP-43) are a major pathological feature of frontotemporal lobar degeneration (FTLD-TDP).

Furthermore, p35/Cdk5 was found to suppress the formation of mutant Huntingtin aggregates, a major pathological feature of HD, in primary cultured neurons.

… a major pathological feature of MLII is indeed potentially treatable using an FDA approved drug currently in therapy for the treatment of several bone diseases.

Deposition of amyloid-beta (Aβ) as a form of senile plaque in the human brain is a major pathological feature of Alzheimer's disease (AD) (Murphy & LeVine, 2010).

A major pathological feature of P. falciparum malaria is that the mature stage IEs sequester from blood circulation by binding to the endothelial lining of blood vessels.

The major pathological feature of SSc is proliferative or obstructive vascular abnormality, involving the small arteries and arterioles in the skin, lungs, heart and kidneys [ 7].

The major pathological features in the brains of AD patients are senile plaques, containing β-amyloid (Aβ), and neurofibrillary tangles with tau protein[1].

Reduction of PVT1 expression by siRNA significantly affected mRNA and protein levels of all ECM components examined, suggesting that PVT1 contributes to ECM deposition in the glomeruli, one of the major pathological features of diabetic nephropathy.

Transgenic mice have been invaluable for understanding molecular mechanisms underlying amyloid peptide generation, but amyloid mice lack two major pathological features of AD, i.e. tauopathy and neuro-degeneration [14] [18].

One of the major pathological features of prion diseases is astrocytosis.

Hence, the two major pathological features of type 2 diabetes including peripheral insulin resistance and defective insulin secretion are both affected by ER stress and UPR.