Sentence examples for major pathological change from inspiring English sources

In AD, the accumulation of Aβ, especially Aβ42, is a major pathological change [7], [8], [36] and the abnormality in neuronal synchronization is well described [4], [5].

No major pathological change was found at necropsy or histopathology making it unlikely that the hyperbilirubinaemia was caused by liver damage.

Dysfunction of any of the above steps will impair normal neurotransmission, which is indeed a major pathological change during the progression of AD [ 4– 6].

As hypomyelination was the major pathological change in the peripheral nerves, we also determined the g-ratio in the ventral funiculus of the spinal cord.

All images were screened for any major pathological changes.

Myocardial apoptosis is one of the major pathological changes of HF.

Ankylosis and joint angle malformation are major pathological changes in CIA, especially at the late stage of the disease [ 20].

Mice homozygous for Wa5 are embryonic lethal, but the heterozygotes are viable and show no major pathological changes, allowing for long-term studies.

Twenty or 90 weeks of LMNA c.1824C>T mutation expression did not cause any major pathological changes in bone (Fig.  1U and Supplementary Material, Fig. S1A and B).

Essentially, the major pathological changes in SpA are characterized by an aberrant bone formation that predominantly affects the spine and large joints asymmetrically [ 6, 7].

Major pathological changes in diabetic patients such as insulin resistance and high levels of glycated hemoglobin (HbA1c) have also been reported in smokers [ 7].