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Thickening is one of the major pathologic changes in diabetic aorta [ 24].
Major pathologic changes were not observed by light microscopy in the tissues from the free-ranging alligator.
The growing body of evidence shows that proliferation and epithelial mesenchymal transition (EMT) of lens epithelial cells (LECs) are the major pathologic changes in development of ASC and PCO.
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Fibrosis is another major pathologic change in diabetic macroangiopathy [ 24– 26].
A major and serious pathologic change of scrub typhus is a focal or disseminated vasculitis due to the destruction of endothelial cell lining of the small vessels, which is manifested as perivascular infiltration of leukocytes [ 17- 19], an increased vascular permeability with extravascular protein loss, and consequently the hypoalbuminemia.
Widespread decrease in FA values in the patients compared with the controls suggests that the pathologic changes extend diffusely to most major white matter tracts.
Additionally, no significant pathologic changes were found in the major organs of animals treated with 31.25 mg/kg PNPC and lower doses compared with the control group, so 31.25 mg/kg dose was ruled out as the toxic dose.
In humans, S. bovis is a major cause of valvular endocarditis and is often associated with preexisting pathologic changes of the colon, underlying disease, and immunosuppression (10 ).
Effects of TCDD resemble pathologic changes in cancer, heart disease, diabetes mellitus, and wasting syndromes, major human diseases.
Furthermore, since LP is a major component of the outer membrane of gram-negative bacteria, LP in culture supernatants of growing Burkholderia cells may induce pathologic changes associated with infections [44].
Ponchiardi, C., Mauer, M. & Najafian, B. Temporal profile of diabetic nephropathy pathologic changes.
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