The major pathogenic hypotheses of depression assumes the involvement of life events (Kendler et al. 1999; Kendler 2008; Keller et al. 2007), biogenic amines (in particular, serotonin; Russo et al. 2007) and stress hormones (cortisol; Holsboer 2000).
Most strikingly, however, the Pex11beta knockout mouse (which has intact peroxisomes) dies of ZS, but shows almost normal peroxisomal metabolism, including normal levels of very long-chain fatty acids and plasmalogens, thus confuting the major pathogenic hypotheses listed above [ 12].
Bacillus remains the major pathogenic bacterium isolated in majority of areas for Bombyx mori [17].
In the early days of the germ theory era many of the major pathogenic microbes were encapsulated or toxigenic bacteria, and this suggested that there were inherent differences between pathogenic and non-pathogenic microbes.
From this joint effort, major pathogenic pathways emerged.
Oxidative stress is a major pathogenic mechanism of lead neurotoxicity.
Cardiomyocyte loss is a major pathogenic mechanism leading to heart failure.
The protein toxins are major pathogenic factors and causally involved in various diseases induced by Clostridia.
Immunological dysregulation is now recognised as a major pathogenic event in sepsis.
The major pathogenic factor of DM is hyperglycemia, which is a significant contributor to the accumulation of AGEs [13, 63].
