Sentence examples for major pathogenic event from inspiring English sources

Immunological dysregulation is now recognised as a major pathogenic event in sepsis.

A large body of evidence suggests that altered production of Aβ is a major pathogenic event in Alzheimer's disease (2).

Although BC cells themselves are suspected to degrade the bone matrix [ 3], their paracrine pro-OC activity is a major pathogenic event driving excessive OC differentiation and hyperactivation, resulting in the formation of bone metastases [ 39, 40].

Oxidative stress is a major pathogenic event that occurs in several liver disorders, ranging from metabolic to proliferative conditions, and is a major cause of liver damage during LT [ 24].

Vascular leakage and impaired fluid absorption from the retinal tissue across the glio-vascular interface are major pathogenic events of edema formation [36].

Intracellular accumulation of lipids, inflammatory responses, and subsequent apoptosis are major pathogenic events of metabolic disorders.

Bacillus remains the major pathogenic bacterium isolated in majority of areas for Bombyx mori [17].

The major pathogenic hypotheses of depression assumes the involvement of life events (Kendler et al. 1999; Kendler 2008; Keller et al. 2007), biogenic amines (in particular, serotonin; Russo et al. 2007) and stress hormones (cortisol; Holsboer 2000).

Mechanisms underlying early degeneration of axons in PD remain unknown, but several lines of evidence have linked this critical pathogenic event to abnormalities in the function of conventional kinesin and cytoplasmic dynein (CDyn), major microtubule-based molecular motors responsible for axonal transport in adult neurons.

From this joint effort, major pathogenic pathways emerged.

Oxidative stress is a major pathogenic mechanism of lead neurotoxicity.