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This concurs with the results of Yildiz et al. [42] who found that mechanical ventilation induced netosis in an animal model of sepsis, but that netosis had no major pathogenic effect.
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While traditional models of Alzheimer's disease focused on large fibrillar deposits of the Aβ42 amyloid peptide in the brain, recent work suggests that the major pathogenic effects may be attributed to SDS-stable oligomers of Aβ42.
Immunological dysregulation is now recognised as a major pathogenic event in sepsis.
Bacillus remains the major pathogenic bacterium isolated in majority of areas for Bombyx mori [17].
Our findings are in agreement with others that APOE is the major pathogenic locus for LOAD, and that further loci of smaller effect remain to be identified [ 16, 17].
Since advanced glycation end products (AGEs) are major pathogenic factors and active inflammation inducers in diabetes mellitus, this study assessed the effects of AGEs on macrophage polarization.
IL-17 producing Th17 cells are now believed to be the major pathogenic T cell subset in EAE/MS and other autoimmune diseases [35], [36], although cause and effect relationships in human health have not been established.
From this joint effort, major pathogenic pathways emerged.
Oxidative stress is a major pathogenic mechanism of lead neurotoxicity.
Thus, SJP-SNU had no pathogenic effect on chicken embryos.
Cardiomyocyte loss is a major pathogenic mechanism leading to heart failure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com