Sentence examples for major pathogenic component from inspiring English sources

Moreover, although MOG accounts for only about 0.1% of total CNS myelin protein, MOG−/− mice showed a delayed onset of EAE when immunized with whole myelin and the clinical signs were significantly milder compared with WT mice, suggesting that anti-MOG response is the major pathogenic component of the autoimmune response directed against myelin.

This gene encodes a transmembrane protein localized to the ER, suggesting that ER dysfunction is a major pathogenic component of Wolfram syndrome.

ITSN-1s is one of the recently identified substrates for the cytotoxic protease granzyme B (GrB), [ 15], raising the possibility that during inflammatory processes, major pathogenic components of pulmonary vascular remodeling, [ 16], ITSN-1s can be cleaved and thus, expression of full-length protein reduced.

The major pathogenic factor of DM is hyperglycemia, which is a significant contributor to the accumulation of AGEs [13, 63].

To date, increased fat consumption is considered the major pathogenic factor of MS and NAFLD.

These data confirm that TNF, apparently, is not a major pathogenic factor in pSS.

Future studies are critical to elucidate the functional relationship between specific components of PRP and major pathogenic mechanisms.

Bacillus remains the major pathogenic bacterium isolated in majority of areas for Bombyx mori [17].

From this joint effort, major pathogenic pathways emerged.

Oxidative stress is a major pathogenic mechanism of lead neurotoxicity.

Cardiomyocyte loss is a major pathogenic mechanism leading to heart failure.