Sentence examples for major oxidative modifications from inspiring English sources

Five structurally identified markers of oxidative damage, representative of three major oxidative modifications of proteins (the direct oxidation-derived-specific protein carbonyls, GSA and AASA, the glycoxidation-derived CEL and the lipoxidation-derived CML and MDAL) were measured by gas chromatography/mass spectrometry (GC/MS) as described previously (Pamplona et al., 2005).

Several major forms of oxidative modifications can occur on amino acid residue side chains, including carbonylation, nitrosylation, and oxidation of methionine to methionine sulfoxide [8].

Lysine residues play a critical role in the function of apoB-100 and are the major targets of oxidative modifications.

As cysteine residues are major target of oxidative modifications, all five cysteines within the redox-sensing domain were potentially involved in the regulation of ubiquitination.

Oxidative stress markers staining revealed increased expression of N-carboxymethyl-lysine (CML), a major product of oxidative modification of glycated proteins, nitro-tyrosine and NOX4, in Timp3 −/− mice (Fig 2D and Supporting Information Figs S8 S10) compared to WT diabetic controls.

Previous studies from this laboratory (Vasilaki et al., 2006) have indicated that measurements of the 3-NT content of the major cytosolic protein CAIII are a more sensitive marker of oxidative modifications to muscle than measurements of total muscle 3-NT content and also indicated that the 3-NT content of muscle CAIII showed a small but significant increase following contractile activity.

Oxidative damage to DNA caused by reactive oxygen species is believed to be a major type of endogenous cellular damage, and more than 80 different oxidative modifications of DNA bases and sugar backbone have been identified to date [1].

The excess oxidative stress was previously reported to induce extensive oxidative modifications on lens proteins especially α-crystalline protein, a major protein component of the mammalian eye lens resulting in the enhanced lens opacity [ 24, 25].

The oxidative modifications of low-density lipoprotein (LDL) are crucial for the atherosclerosis process.

Oxidative effect on proteins has received considerable attention especially cysteine residues as they are sensitive to oxidative modifications [6].

Oxidative modifications to DNA.