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BA synthesis represents a major output pathway of cholesterol from the body.
The striatum and the amygdala central nucleus have projections from substantia nigra, and the stria terminalis serves as a major output pathway of the amygdala (Supplementary Fig. 8).
The major output pathway of ALS, defining its name, is the inability of dying motoneurons, despite enlargement of motor units, to give trophic support to dependent myofibers.
We show that one major output pathway of light signalling in Trichoderma reesei is regulation of glycoside hydrolase genes and the degradation of hemicellulose building blocks.
The cAMP pathway is considered the major output pathway of heterotrimeric G-protein signaling [ 40] and would hence be likely to act as a coincidence detector between nutrient and light signaling.
We show that members of all glycoside hydrolase families can be subject to light dependent regulation, hence confirming nutrient utilization including plant cell wall degradation as a major output pathway of light signalling.
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These findings point to dysregulation of striatal TRH expression in these major output pathways of the basal ganglia as a potential central factor in the induction of LIDs.
The fornix a major input and output pathway of the HC has long been considered to form part of an extended hippocampal system, both in terms of its role in episodic memory (Aggleton and Brown, 1999; Metzler-Baddeley et al., 2011), but also in spatial processing (Bird and Burgess, 2008).
In Arabidopsis thaliana, induction of the expression of a florigen, FLOWERING LOCUS T (FT) protein, is a major output of the photoperiodic flowering pathway.
We showed the functions of PhLP1, GNB1 and GNG1 in the same pathway, with one major output being the regulation of transcription of glycoside hydrolase genes including cellulase genes in T. reesei.
The insulin-like signalling pathway components phosphorylate and inactivate the FOXO transcription factor DAF-16 that is a major output of this cascade [ 32].
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