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11 However, people often have several health and social risk factors impacting major outcomes such as still birth.
As another limitation, major outcomes such as hospital admissions or emergency room visits were not available in these databases.
In fact, in terms of major outcomes such as DAS remission and ACR70, the results are less convincing.
There are insufficient published data to determine if treating CMV impacts upon major outcomes such as colectomy rates and mortality [ 11].
Nevertheless, the authors acknowledge the many limitations of their study (for example, heterogeneity of PCT protocols) and emphasize that further information on major outcomes, such as length of stay and mortality, is required from future studies.
One systematic review and three meta analyses of these trials have been published [ 30- 33], but have come to different conclusions concerning benefits on major outcomes, such as mortality and hospital admissions.
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Socioeconomic and psychosocial gradients in smoking are a major contributor to socioeconomic gradients in major health outcomes such as life expectancy and quality of life.
Therefore uncertainty remains regarding the benefits of direct thrombin inhibitors on major cardiovascular outcomes such as death or myocardial infarction and the balance of any such benefits against the risk of major bleeding.
One of the major outcomes of such interactome maps would be a wiring diagram that could be used to make sense of complex traits starting from currently available Genome-Wide Association studies (GWAS), at least those variants producing non-synonymous mutations in protein-coding genes, cancer genome sequencing efforts such as The Cancer Genome Atlas (TCGA), and key consortia such as ENCODE.
Delirium is also associated with major adverse outcomes such as increased mortality, functional impairment, prolonged hospitalization, and increased cost of care [ 14- 16].
A similar group of patients without significant MR were matched and followed-up in a similar manner for major clinical outcomes such as mortality and heart failure rehospitalisation.
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