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Exact(7)
There was no significant difference in the blood circulation between polymeric carrier and payload; the carriers 111In-2PP and 125I-2P) showed similar retention of radioactivity in both tumor and major organs except kidney.
In vivo study shows that the circulation time of rNGO-PEG/ICG in the mouse body can sustain up to 6 h upon intravenous injection; while after 1 day, no obvious accumulation of rNGO-PEG/ICG is found in any major organs except the tumor regions.
On PID 3 GFP signal was detected throughout the mesentery, in all abdominal organs by PID 5 and in most major organs, except for the heart and brain by PID 6. Infected animals treated with 25 mg/kg of cidofovir also began showing signs of viral replication on PID 1, however, the fluorescent signal was limited only to discrete foci throughout the course of the infection.
All mice were also examined carefully at necropsy for evidence of gross metastatic disease in all major organs except the brain.
As shown in Table 1, the bimetallic complex, Gd6 LGa, indeed displayed a rapid and efficient clearance profile from all major organs except kidneys in normal mice.
A long time between cardiac arrest and ECMO "pump on" may be tolerated by many major organs except the brain, which is the organ most sensitive to hypoxia.
Similar(53)
Vinflunine administration was delayed by 1 or 2 weeks in the case of significant haematological or nonhaematological toxicity (grade >2 toxicity impacting a major organ except for alopecia).
As shown in Fig. 8a, we found that MDR tumors took up approximately 0.8% of MBO-asGCS and that amount was greater than these in other tissues (pancreas, small intestine, stomach, large intestine, serum, lung, brain, heart), excepting liver and kidneys that are the major organs for oligonucleotide degradation (5.8% in liver, 0.99% in kidney).
Similarly, major organs collected showed no observable histological changes in the three groups except for the tumor.
Both IO Pc 4 NPs also showed a higher level of Pc 4 biodistribution in all major organs than free Pc 4 at 4 h, but the Pc 4 level in most of the organs except the skin was largely reduced after 48 h.
Litvinenko's heart rate was becoming abnormal; his major organs failing.
Related(20)
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Justyna Jupowicz-Kozak
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