In this study, we assumed deep phylogenetic origins for large DNA virus lineages (i.e. before the divergence of major phyla of cellular organisms), which have been indicated by the analyses conserved genes (e.g. DNA polymerase) [ 5, 78].
Interestingly, the electrostatic potential surface charge distribution on the primase binding surface of helicases show major striking differences in different organisms which may be responsible for the differences in binding stability of DnaB-DnaG complex (Figure 5B).
Reversible binding of O 2 is closely associated to the major function of Hbs in organisms, which is the transport of O 2. Binding of NO by Hbs is essential to NO-detoxification via a NO-dioxygenase activity.
GSH (an important part of the nonenzymatic antioxidant system) is a major nonprotein thiol in living organisms, which plays a central role in coordinating the body's antioxidant defense processes.
Instead, they are based on "the belief in the functionality of the behaviors of living organisms, which is illustrated by major principles such as the adaptability of organisms to their environment and the complementarity between structure and function" (p. 66).
In our study, the plant extracts exhibited significant antimicrobial activity against the pathogenic organisms which are considered as a major component for diseases.
This can lead to the major reverse biological transition from cells in pluricellular organisms, which obey constrains of the whole, to unicellular organisms, which independently strive to survive and multiply.
Now our major concern has ceased to be these and other disease organisms, which were once omnipresent; sanitation, better living conditions, and new drugs have given us a high degree of control over infectious disease.
Hence, one of the major current challenges in the field is the network inference for less-studied organisms which are either pathogens or are industrially important.
Brucellosis causes abortion which is the major means of spread by infected afterbirth or fetus as well as excretion of excessive organisms which can easily be acquired by susceptible animals.
