Sentence examples for major open issues from inspiring English sources

In this paper, these major open issues of the reference TC layout are addressed and a TC reconfiguration proposal, featuring arranging the lithium quench tank inside the TC, is introduced.

This paper briefly discusses the major open issues relative to the understanding of the solar corona and the origin of the solar wind in the context of the opportunities offered by the Solar Orbiter, future mission of the European Space Agency.

Although the design of the TC, to a large extent, inherits that of the reference IFMIF-EVEDA (Engineering Validation and Engineering Design Activities) TC, design justifications are required to solve the existing major open issues such as cavitation of the lithium flow, activation and maintainability of key components, and etc.

The molecular and cellular mechanisms of the primary brain dysfunction leading to the onset of a migraine attack and to susceptibility to cortical spreading depression (CSD), the neurophysiological correlate of migraine aura and a likely trigger of the headache mechanisms, remain largely unknown and major open issues in the neurobiology of migraine.

A major open issue for this class is whether truthfulness affects the polynomial-time implementation.

A major open issue in the design and operation of cable-direct-driven-robots (CDDRs) is ensuring tensile cable forces for any admissible motion of the CDDR.

In our point of view, these are the main issues still open regarding the identification of attacks against the detection of PU activity, one major open issue regarding security in CR environments.

In spite of the challenges addressed by our research (mainly challenges 1 4 and 6), a major open issue enumerated by Kulesza et al. [80] concerns the lack of experimental studies to assess the usefulness and feasibility of AO testing approaches, as well as the generalisation of results.

However, even for simple model problems, quasi-optimality of adaptive boundary element methods is a major open issue, cf. [3,18,31].

In [17], the authors identify security and privacy issues as one of the major open research issues in the development of medical cyber-physical systems (MCPS), especially considering that interoperability capabilities will open up new attack surfaces that can be misused to harm patients by, e.g., manipulation of data or direct access to critical system components.

In [7], architectures to support cognitive radio (CR) networks in SG applications, major challenges, and open issues have been discussed.